Alterations in Corrected QT Interval Following Liver Transplant in Patients With End‐Stage Liver Disease

Abstract

Abstract Background: Studies have demonstrated that patients with end‐stage liver disease (ESLD) often have a prolonged corrected QT interval (QTc) with variable changes in the QTc post‐transplant. We sought to characterize the prevalence and degree of QTc prolongation in ESLD patients, identify risk factors for QTc prolongation, and assess changes in QTc following transplant. Hypothesis: QTc interval is prolonged in ESLD patients pre‐transplant due to a variety of risk factors and shortens following liver transplantation. Methods: We conducted a retrospective, multicenter study utilizing 2 large liver‐transplant databases. QTc intervals were calculated utilizing Bazett's formula. The cutoff used for prolonged QTc was 440 milliseconds for men and 460 milliseconds for women. Results: There were 269 patients (169 men, 100 women) included in the final analysis. The mean pre‐transplant QTc was prolonged (449.0 ms), whereas the mean post‐transplant QTc shortened and was within normal limits (416.7 ms) ( P < 0.0001). QTc shortened after transplant in 87% of patients. QTc normalized in 70% of patients. Age and Model for End‐Stage Liver Disease (MELD) score were not predictive of prolonged QTc at baseline. Conclusions: ESLD patients often have a prolonged QTc, which frequently shortens or normalizes after transplant. Screening for prolonged QTc is warranted if medications known to prolong the QTc interval are used in ESLD patients pre‐transplant. MELD score, age, and sex were not predictive of prolonged QTc at baseline. Copyright © 2010 Wiley Periodicals, Inc. Ms. Lorenze is a student at the University of Wisconsin whose involvement on this project included, but was not limited to, data collection and analysis and manuscript editing. The authors have no funding, financial relationships, or conflicts of interest to disclose.