Age- and Sex-Related Differences in Clinical Manifestations in Patients With Congenital Long-QT Syndrome

Abstract

Among LQTS patients, the risk of cardiac events was higher in males until puberty and higher in females during adulthood. The same pattern was evident among LQT1 gene carriers. Unknown sex factors modulate QT duration and arrhythmic events, with preliminary evidence of gene-specific differences in age-sex modulation.