Direct displacement and coupling of prop-2-ynylic acetates with organocuprates

Abstract

The direct displacement of the acetate in 1-trimethylsilyl-3-acetoxyoct-1-yne (6) by the alkyl substituent of dialkylorganocuprates, and the lithium dimethylcuprate-medrated coupling of 3-acetoxy-1-trimethylsilylpent-4-en-1-yne (8b) are reported.