Transdermal delivery of insulin using a solid-in-oil nanodispersion enhanced by arginine-rich peptides

Abstract

A solid-in-oil nanodispersion that utilizes an oil-based vehicle of proteins was developed as a unique protein-delivery system into the skin. We enhanced the permeability of insulin and accomplished transdermal delivery of insulin by the collaborative effects of a S/O nanodispersion and arginine-rich peptides.