Non-ATP competitive protein kinase inhibitors as anti-tumor therapeutics

Effects of a selective inhibitor of the Abl tyrosine kinase on the growth of Bcr–Abl positive cells

Brian Druker, Shu Tamura, Elisabeth Buchdunger et al. · Nature Medicine · 1996 · 3.6K citations

Signal Transduction, Cell Regulation, Abl Tyrosine Kinase +10

The selectivity of protein kinase inhibitors: a further update

Jenny Bain, Lorna Plater, Matt Elliott et al. · Biochemical Journal · 2007 · 2.5K citations · Full text

The Molecular Basis for Phosphodependent Substrate Targeting and Regulation of Plks by the Polo-Box Domain

Andrew E. H. Elia, Peter Rellos, L.F. Haire et al. · Cell · 2003 · 763 citations · Full text

Polo-box Domain, Protein Function, Signal Transduction +12

A Mammalian Scaffold Complex That Selectively Mediates MAP Kinase Activation

Alan J. Whitmarsh, Julie Cavanagh, Cathy Tournier et al. · Science · 1998 · 655 citations

Reductive Stress, Molecular Physiology, Signal Transduction +15

JNK2 contains a specificity-determining region responsible for efficient c-Jun binding and phosphorylation.

Tuula Kallunki, Bing Su, Igor F. Tsigelny et al. · Genes & Development · 1994 · 636 citations · Full text

Catalytic Pocket, Efficient C-jun Binding, Molecular Biology +18