Concepedia

Privileged structure-based ligands for melanocortin receptors—tetrahydroquinolines, indoles, and aminotetralines

Matthew J. Fisher, Ryan T. Backer, Saba Husain, Hansen M. Hsiung, Jeffrey T. Mullaney, Thomas P. O’Brian, Paul L. Ornstein, Roger R. Rothhaar, John M. Zgombick, Karin Briner

Bioorganic & Medicinal Chemistry Letters · 2005 · 24 citations · 14 references

DOIFull text

Open access

Concepts

References

14

Methods for drug discovery: development of potent, selective, orally effective cholecystokinin antagonists

B. Evans, Kenneth E. Rittle, Mark G. Bock et al. · Journal of Medicinal Chemistry · 1988 · 1.4K citations · Full text

, , +13

Scope and Limitations of the Pd/BINAP-Catalyzed Amination of Aryl Bromides

John P. Wolfe, Stephen L. Buchwald · The Journal of Organic Chemistry · 2000 · 430 citations

, , +16

Design and biological activities of L-163,191 (MK-0677): a potent, orally active growth hormone secretagogue.

Arthur A. Patchett, Ravi P. Nargund, James R. Tata et al. · Proceedings of the National Academy of Sciences · 1995 · 331 citations

, , +11

Design and Pharmacology of <i>N</i>-[(3<i>R</i>)-1,2,3,4-Tetrahydroisoquinolinium- 3-ylcarbonyl]-(1<i>R</i>)-1-(4-chlorobenzyl)- 2-[4-cyclohexyl-4-(1<i>H</i>-1,2,4-triazol- 1-ylmethyl)piperidin-1-yl]-2-oxoethylamine (<b>1</b>), a Potent, Selective, Melanocortin Subtype-4 Receptor Agonist

Iyassu K. Sebhat, William J. Martin, Zhixiong Ye et al. · Journal of Medicinal Chemistry · 2002 · 193 citations · Full text

, , +11

Recognition of Privileged Structures by G-Protein Coupled Receptors

Kent Bondensgaard, Michael Ankersen, Henning Thøgersen et al. · Journal of Medicinal Chemistry · 2004 · 179 citations · Full text

, , +17