Enzyme models and their relation to inclusion compounds

Abstract

Abstract Syntheses of high polymers with active groups of the hemin and chlorophyll series and their optical properties, the shifts of the band maxima, and the change of the acid dissociation constants of the active groups are discussed. This touches upon the question of the existence of inclusion compounds in solution. The existence of true compounds in solution was proved by applying the law of mass action to several known inclusion systems. The acid dissociation constants of some dyes and their cyclodextrin inclusion compounds were determined by means of prototropy equilibria. The system serum albumin/methyl orange and macromolecular compounds with active groups of the hemin and chlorophyll series show a similarity to true inclusion compounds in solution, which suggests the existence of inclusion regions in the high polymers in question. Furthermore, syntheses of D ‐, L ‐, and DL ‐forms of polyphenylalanines substituted by active groups, their optical and catalytic properties, and first experiments regarding a synthesis of cytochrome c models are discussed.