Biochemical effects of folate-based inhibitors of thymidylate synthase in MGH-U1 cells

ICI D1694, a quinazoline antifolate thymidylate synthase inhibitor that is a potent inhibitor of L1210 tumor cell growth in vitro and in vivo: a new agent for clinical study.

A.L. Jackman, G A Taylor, William Gibson et al. · PubMed · 1991 · 359 citations

Medicine, Medicinal Chemistry, Pharmacology +10

An Isotopic Assay for Thymidylate Synthetase^*

DeWayne Roberts · Biochemistry · 1966 · 212 citations

Life Sciences, Biochemistry, Molecular Biology +8

Mechanism of cell death following thymidylate synthase inhibition: 2'-deoxyuridine-5'-triphosphate accumulation, DNA damage, and growth inhibition following exposure to CB3717 and dipyridamole.

Nicola J. Curtin, Adrian L. Harris, G. Wynne Aherne · PubMed · 1991 · 164 citations

Medicine, Oncology, Pharmacology +14

Effects of 3′-azido-3′-deoxythymidine on the deoxynucleotide triphosphate pools of cultured human cells

Lloyd Frick, Donald J. Nelson, M H St Clair et al. · Biochemical and Biophysical Research Communications · 1988 · 129 citations

Life Sciences, Biochemistry, Molecular Biology +12

Biochemical and cellular pharmacology of 1843U89, a novel benzoquinazoline inhibitor of thymidylate synthase.

David S. Duch, Sheila D. Banks, I K Dev et al. · PubMed · 1993 · 114 citations

Life Sciences, Biochemistry, Pharmacology +9