Mapping the interaction site of prion protein and Sho

Conversion of alpha-helices into beta-sheets features in the formation of the scrapie prion proteins.

K M Pan, M. A. Baldwin, Jack Nguyen et al. · Proceedings of the National Academy of Sciences · 1993 · 2.3K citations

Life Sciences, Biochemistry, Molecular Biology +17

Mice devoid of PrP are resistant to scrapie

Hansruedi Büeler, Adriano Aguzzi, Andreas W. Sailer et al. · Cell · 1993 · 2.1K citations · Full text

Veterinary Medicine, Infectious Diseases, Pathobiology +8

Normal development and behaviour of mice lacking the neuronal cell-surface PrP protein

Hansruedi Büeler, Marek Fischer, Yolande Lang et al. · Nature · 1992 · 1.7K citations · Full text

Life Sciences, Neurobiology, Neuroscience +13

Dramatic Aggregation of Alzheimer Aβ by Cu(II) Is Induced by Conditions Representing Physiological Acidosis

Craig Atwood, Robert D. Moir, Xudong Huang et al. · Journal of Biological Chemistry · 1998 · 1K citations · Full text

Life Sciences, Biochemistry, Neurobiology +17

Ataxia in prion protein (PrP)-deficient mice is associated with upregulation of the novel PrP-like protein doppel

Richard C. Moore, Inyoul Y. Lee, Gregory L. Silverman et al. · Journal of Molecular Biology · 1999 · 519 citations

Veterinary Medicine, Neurology, Neuroscience +16