Oxidation therapy: the use of a reactive oxygen species-generating enzyme system for tumour treatment

Toxic DNA Damage by Hydrogen Peroxide Through the Fenton Reaction in Vivo and in Vitro

James A. Imlay, Sherman M. Chin, Stuart Linn · Science · 1988 · 1.6K citations

Life Sciences, Molecular Biology, Toxicology +17

Comparison of In Vitro Anticancer-Drug-Screening Data Generated With a Tetrazolium Assay Versus a Protein Assay Against a Diverse Panel of Human Tumor Cell Lines

Larry Rubinstein, Robert H. Shoemaker, Kenneth D. Paull et al. · JNCI Journal of the National Cancer Institute · 1990 · 931 citations

Medicine, Oncology, Pharmacology +14

Mechanism of action, metabolism, and toxicity of buthionine sulfoximine and its higher homologs, potent inhibitors of glutathione synthesis.

Owen W. Griffith · Journal of Biological Chemistry · 1982 · 701 citations · Full text

Life Sciences, Biochemistry, Pharmacology +15

Hydrogen peroxide-induced injury of cells and its prevention by inhibitors of poly(ADP-ribose) polymerase.

Ingrid U. Schraufstätter, Paul A. Hyslop, Daniel B. Hinshaw et al. · Proceedings of the National Academy of Sciences · 1986 · 462 citations · Full text

Life Sciences, Biochemistry, Cell Biology +17

In vivo formation of single-strand breaks in DNA by hydrogen peroxide is mediated by the Haber-Weiss reaction

A C Mello Filho, Rogério Meneghini · Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression · 1984 · 349 citations

Life Sciences, Biochemistry, Molecular Biology +12