Nebulized Racemic Epinephrine by IPPB for the Treatment of Croup. A Double-Blind Study

Abstract

• Racemic epinephrine has been advocated for the treatment of croup, but controlled studies have not proved it more effective than saline. Twenty patients (aged 4 months to 5 years) hospitalized with acute croup and persistent inspiratory stridor at rest were randomly assigned to one of two treatment groups: saline or racemic epinephrine, both nebulized and delivered by intermittent positive pressure breathing. Clinical scores were significantly improved ( P P P ( Am J Dis Child 132:484-487, 1978)