Defective Apoptotic Cell Phagocytosis Attenuates Prostaglandin E ₂ and 15-Hydroxyeicosatetraenoic Acid in Severe Asthma Alveolar Macrophages

Abstract

A decrease in AMphis LPS-responsiveness in severe asthma is manifested by defective apoptotic cell uptake and reduces secretion of inflammatory mediators. This may contribute to the chronicity of inflammation and remodeling in lungs of patients with asthma.