Conversion of Androgen to Estrogen and Other Steroids in the Vertebrate Brain

Abstract

Aromatase activity has been detected in the central nervous system (CNS) of representatives of each major vertebrate group with the exception of the Agnatha. 5a-reductase and 17/3-oxidoreductase are also present in brain tissues of many vertebrates and in the cerebral ganglion of the lobster. These comparative studies together with autoradiographic, physiological, and behavioral data in mammals and selected nonmammalian species support the view that metabolism in situ is an important component of androgen action and a general characteristic of the vertebrate brain.