Proceedings of SPIE, the International Society for Optical Engineering/Proceedings of SPIE · 1998 · 29 citations · 0 references
Natural SciencesCancer BiologyOncologyHistopathologySpectroscopic AnalysisSpectroscopyAbsorption SpectroscopyCancer DiagnosisInfrared InstrumentationInfrared SpectroscopyOptical SpectroscopyTumor CharacterizationBiological Sample StorageInfrared Absorption SpectraInfrared Absorption SpectroscopyInfrared SpectraInfrared Spectroscopic AnalysisPathologic HistologyQuantitative Spectral AnalysisSample Storage Conditions
IR spectroscopy is proving to be a powerful tool for the study and diagnosis of cancer. The application of IR spectroscopy to the analysis of cultured tumor cells and grading of breast cancer sections is outlined. Potential sources of error in spectral interpretation due to variations in sample histology and artifacts associated with sample storage and preparation are discussed. The application of statistical techniques to assess differences between spectra and to non-subjectively classify spectra is demonstrated.