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PLASMA MEMBRANES IN ACUTE LIVER INJURY. BIOCHEMICAL CHANGES INDUCED BY CARBON TETRACHLORIDE
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1971
Year
Single High DoseToxicological MechanismOxidative StressBioanalysisToxicologyHepatotoxicityClinical ToxicologyEarly StageHealth SciencesBiochemistryLiver PhysiologySummary Plasma MembranesExperimental ToxicologyPharmacologyDrug-induced Liver InjuryLiverHepatologyPhysiologyAcute Liver FailureLiver DiseaseMetabolismMedicine
Summary Plasma membranes isolated from liver of rats given a single high dose of carbon tetrachloride were compared with controls, with respect to activity of three enzymes, 5′‐mononucleotidase, Na + ‐K + ‐ATPase and Mg 2+ ‐ATPase. All three enzymes showed decreases in activity in the period 2½‐18 h following dosing with CCl 4 . This is considered as direct evidence that biochemical changes arise in the liver‐cell plasma membrane at an early stage after poisoning of rats with this hepatotoxin.