Pharmacokinetic model incorporating mechanism-based inactivation of CYP2D6 can explain both non-linear kinetics and drug interactions of paroxetine - Concepedia

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Pharmacokinetic model incorporating mechanism-based inactivation of CYP2D6 can explain both non-linear kinetics and drug interactions of paroxetine

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References

2013

Year

Akiko Mikami, Hisakazu Ohtani, Satoko Hori, Yasufumi Sawada

International Journal of Clinical Pharmacology and Therapeutics

Abstract

The developed model enabled us to quantitatively estimate drug-drug interactions of PRX and CYP2D6 substrate drugs, and to predict optimal dosage regimens.