Transplantation · 1965 · 75 citations · 0 references
Life SciencesDermatologyImmunologyClinical ImmunologyHypersensitivityTransplant ImmunologyAntibody CharacterizationAntibody-antigen RecognitionComplement SystemCytotoxic T Lymphocyte ResponsesAntibodiesComplement ComponentsHuman Leukocyte Antigen AntibodiesHuman Leukocyte AntigensImmune-mediated Cell Lysis
The time-related development of lymphocytotoxic antibodies in humans after skin homografting and/or intradermal leukocyte injection has been detailed. The antibodies were shown to reside chiefly in the γ2-globulin fraction of serum and to be individual-specific. They could be selectively adsorbed with positively-reacting cells. Various parameters of the cytotoxic test system were studied with emphasis on the nature of its “complement” requirement.