Molecular Pharmaceutics · 2004 · 32 citations · 7 references
PharmacyOncologyPharmaceuticsDrug DeliveryNanoparticle Drug DeliveryTargeted Drug DeliveryLiposomal FormulationsLiposome-based DeliveryNanomaterials For Drug DeliveryNanomedicineNanoparticle DesignReactive Oxygen SpeciesAnticancer Drug LoadingCationic LiposomesFenton ReactionFenton-like ReactionsLiposomal Co-deliveryLiposomal NanocarriersLiposomesSuperoxide Dismutase Function
A novel design of anticancer drug delivery system, based on an electrostatic binding of negatively charged liposomes and cationic metalloporphyrins under physiological conditions, is reported. A lack of cytotoxicity of the iron(III) porphyrin-loaded liposomes and an efficient generation of a toxic hydroxyl radical (OH • ) from a superoxide anion radical (O 2 - • ) through the iron(III)-catalyzed dismutation and the Fenton-like reaction allow for a targeted necrosis of tumor cells where the concentration of O 2 - • is locally increased as a result of the reduced activity of superoxide dismutase and catalase in these cells. Keywords: Anticancer drug delivery system; liposome; cationic metalloporphyrins; superoxide anion radical; hydroxyl radical
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