Is there a genetic factor in flecainide toxicity?

Abstract

Thirdly, we measured the pressure in 31 bottles used by ward nurses at this hospital.Subsequently 52 patients were specifically asked not to inject air.After using a whole bottle they completed a questionnaire and recorded whether they found this to be easier, whether they found it difficult to draw up insulin, and whether air bubbles were a problem.In the first study the mean pressure fell rapidly to below -39 9 kPa after 3 ml insulin was withdrawn and subsequently fell more gradually to -58-5 kPa.No difficulty was experienced either in withdrawing the plunger or with air bubbles.In the second study pressures in 31 of the 81 bottles were close to atmospheric pressure (±0 07 kPa) (figure).The pressure was -13-3 kPa or less in 24 bottles, being below -39 9 kPa in 15, which suggested that air had not been injected before insulin was withdrawn.There was no significant difference in mean age, duration of treatment, or insulin dose between the 24 patients who provided these bottles and the remaining 57.The pressure in the 31 bottles used by nurses was below -13-3 kPa in 23 (figure), and values above -0 7 kPa were found in only four.The questionnaires from the 52 patients who did not add air showed that 42 found it easier, 47 found no difficulty in withdrawing insulin, and 40 did not find that air bubbles were a problem.