Hypoxic response elements control expression of human vascular endothelial growth factor₁₆₅ genes transferred to ischemia myocardium <i>in vivo</i> and <i>in vitro</i>

Abstract

This study suggested that 9HRE can effectively control hVEGF(165) gene expression in vivo and in vitro. It has feasibility for using the HIF-1-HRE system for regulation of angiogenic factor expression in ischemia heart.