Pigment epithelium-derived factor attenuates myocardial fibrosis via inhibiting Endothelial-to-Mesenchymal Transition in rats with acute myocardial infarction

Hao Zhang, Hongliang Hui, Zhimin Li, +10

Scientific Reports

Retinoic acid receptor β2 is epigenetically silenced either by DNA methylation or repressive histone modifications at the promoter in cervical cancer cells

Zhongming Zhang, Keiichiro Joh, Hitomi Yatsuki, +7

Cancer Letters

ChromatinTranscriptional RegulationRepressive Histone ModificationsChromatin StructureChromatin Remodeling +13

PEDF and 34-mer inhibit angiogenesis in the heart by inducing tip cells apoptosis via up-regulating PPAR-γ to increase surface FasL

Hao Zhang, Tengteng Wei, Xia Jiang, +8

APOPTOSIS

Developmental BiologyAngiogenesisApoptosisCell DeathVascular Biology +7

PEDF increases GLUT4-mediated glucose uptake in rat ischemic myocardium via PI3K/AKT pathway in a PEDFR-dependent manner

Yanliang Yuan, Xiucheng Liu, Haoran Miao, +7

International Journal of Cardiology

Cardiac MuscleMetabolic RemodelingInsulin SignalingCellular PhysiologyGlut4-mediated Glucose Uptake +14

PEDF is an antifibrosis factor that inhibits the activation of fibroblasts in a bleomycin-induced pulmonary fibrosis rat model

Xichun Qin, Caili Jia, Jingtian Liang, +9

Respiratory Research

Angiogenic function of astragaloside IV in rats with myocardial infarction occurs via the PKD1‑HDAC5‑VEGF pathway

Lei Yang, Nuan Liu, Wei Zhao, +5

Experimental and Therapeutic Medicine

Angiogenic FunctionThrombosisCardiomyopathyCurrent StudyAngiogenesis +12

Pigment Epithelium–Derived Factor Increases Native Collateral Blood Flow to Improve Cardiac Function and Induce Ventricular Remodeling After Acute Myocardial Infarction

Xiucheng Liu, Zhiwei Liu, Jiali Chen, +8

Journal of the American Heart Association

PEDF attenuates hypoxia-induced apoptosis and necrosis in H9c2 cells by inhibiting p53 mitochondrial translocation via PEDF-R

Xiaoyu Wang, Yiqian Zhang, Peng Lü, +4

Biochemical and Biophysical Research Communications

H9c2 CellsMitochondrial FunctionBiochemistryP53 Mitochondrial TranslocationApoptosis +6

Hypoxic response elements control expression of human vascular endothelial growth factor₁₆₅ genes transferred to ischemia myocardium <i>in vivo</i> and <i>in vitro</i>

Bo Jiang, Hongyan Dong, Zhongming Zhang, +3

The Journal of Gene Medicine

Cell penetrating peptide modified M2 macrophage derived exosomes treat spinal cord injury and rheumatoid arthritis by loading curcumin

Zhuo Li, Yajiang Yuan, Zhongming Zhang, +7

Materials & Design

ImmunologyExtracellular MicrovesiclesBiological TherapyBiomedical EngineeringImmunotherapy +16