Peripheral contribution of <scp>NGF</scp> and <scp>ASIC</scp>1a to colonic hypersensitivity in a rat model of irritable bowel syndrome

Abstract

Our data suggest that peripheral NGF and ASIC1a concomitantly contribute to the development of butyrate-induced CHS NGF-ASIC1a interplay may have a pivotal role in the sensitization of colonic sensory neurons and as such, could be considered as a potential new therapeutic target for IBS treatment.