Hypertension Due to Primary Renal Ischemia

Abstract

THE literature now contains incontrovertible evidence that some forms of severe hypertension in man can be cured by revascularization or by nephrectomy.1 , 4 The prime example is hypertension associated with relative renal ischemia, the most clearcut mechanism being partial obstruction to renal-artery flow, similar in many respects to the "Goldblatt kidney" in dog,.5 , 6 From time to time, interest has centered on the juxtaglomerular apparatus in these kidneys. The juxtaglomerular apparatus consists of the macula densa and the juxtaglomerular body. The latter is made up of epithelioid cells grouped about the afferent arteriole. Goormaghtigh7 first postulated an endocrine function for the juxtaglomerular . . .