CD4+ T Cell Depletion during all Stages of HIV Disease Occurs Predominantly in the Gastrointestinal Tract

Jason M. Brenchley, Timothy W. Schacker, Laura E. Ruff, +8

The Journal of Experimental Medicine

Dramatic Rise in Plasma Viremia after CD8+ T Cell Depletion in Simian Immunodeficiency Virus–infected Macaques

Xia Jin, Daniel Bauer, Sarah Tuttleton, +11

The Journal of Experimental Medicine

Plasma ViremiaImmunodeficienciesImmunologyCell PopulationImmunotherapy +15

Gastrointestinal Tract as a Major Site of CD4 ⁺ T Cell Depletion and Viral Replication in SIV Infection

Ronald S. Veazey, MaryAnn DeMaria, Laura V. Chalifoux, +7

Science

Massive infection and loss of memory CD4+ T cells in multiple tissues during acute SIV infection

Joseph J. Mattapallil, Daniel C. Douek, Brenna J. Hill, +3

Nature

Viral PersistenceMultiple TissuesHuman RetrovirusAcute Siv InfectionImmunology +3

Primary HIV-1 Infection Is Associated with Preferential Depletion of CD4+ T Lymphocytes from Effector Sites in the Gastrointestinal Tract

Saurabh Mehandru, Michael A. Poles, Klara Tenner‐Racz, +6

The Journal of Experimental Medicine

Shorter Survival in Advanced Human Immunodeficiency Virus Type 1 Infection Is More Closely Associated with T Lymphocyte Activation than with Plasma Virus Burden or Virus Chemokine Coreceptor Usage

Janis V. Giorgi, Lance E. Hultin, Jane A. McKeating, +9

The Journal of Infectious Diseases

CD8+ T-cell responses to different HIV proteins have discordant associations with viral load

Photini Kiepiela, Kholiswa Ngumbela, Christina Thobakgale, +27

Nature Medicine

Cd8+ T-cell ResponsesDiscordant AssociationsDifferent Hiv ProteinsHuman RetrovirusImmunology +9

Peak SIV replication in resting memory CD4+ T cells depletes gut lamina propria CD4+ T cells

Qingsheng Li, Lijie Duan, Jacob D. Estes, +7

Nature

Peak Siv ReplicationAdaptive Immune SystemPathogenesisImmunologyAutoimmunity +4

Severe CD4⁺T-Cell Depletion in Gut Lymphoid Tissue during Primary Human Immunodeficiency Virus Type 1 Infection and Substantial Delay in Restoration following Highly Active Antiretroviral Therapy

Moraima Guadalupe, Elizabeth Reay, Sumathi Sankaran, +4

Journal of Virology

Substantial DelayImmunodeficienciesT-regulatory CellImmunologyPathology +18

Persistent immune activation in HIV-1 infection is associated with progression to AIDS

Mette D. Hazenberg, Sigrid A. Otto, Birgit HB van Benthem, +6

AIDS