American Journal of Medical Genetics Part B Neuropsychiatric Genetics · 2007 · 67 citations · 33 references
Life SciencesGeneticsMolecular GeneticsDementiaHuman GeneticsMedical GeneticsAlzheimer DiseaseCandidate Gene StudiesDiabetes MellitusDisease Susceptibility LociGenetic SusceptibilityGenotype-phenotype Association AnalysisAlzheimer Disease RiskDementia Risk LociDisease Susceptibility AssociationGene-disease Association ModelingGenetic PolymorphismsReplication Study DesignRisk Gene VariantsType 2 Diabetes Susceptibility
Epidemiological evidence supports the existence of a possible link between type II diabetes mellitus (T2DM) and late-onset Alzheimer's disease (LOAD). Polymorphisms from candidate genes for T2DM were genotyped in a two-stage approach to identify novel risk factors for LOAD. One hundred fifty-two polymorphisms were initially genotyped in a case:control cohort: nine SNPs showed individual association with disease status under at least one genetic model, while an additional two SNPs showed a haplotype association. In a replication study, we confirmed significant association of SNPs within three genes--PPARgamma, SOS2, and PCK1--with Alzheimer's disease. In particular, our data suggest that the effect of variants within these genes might be influenced by gender.
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Haploview: analysis and visualization of LD and haplotype maps
Jeffrey C. Barrett, Ben Fry, Julian Maller et al. · Bioinformatics · 2004 · 14.7K citations · Full text
Correlative Memory Deficits, Aβ Elevation, and Amyloid Plaques in Transgenic Mice
Karen Hsiao, Paul F. Chapman, Steven P. Nilsen et al. · Science · 1996 · 4.2K citations