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The lignan glycosides lyoniside and saracoside poison the unusual type IB topoisomerase of Leishmania donovani and kill the parasite both in vitro and in vivo

Medicinal ChemistryLignan GlycosidesLeishmania DonovaniBiochemistryAntiparasitic AgentMedicineNatural SciencesParasitic ProtozoaGlycobiologyAfrican TrypanosomiasisPathologyPharmacologyVisceral LeishmaniasisParasitologyDrug Discovery