Concise Synthesis, Preparative Resolution, Absolute Configuration Determination, and Applications of an Atropisomeric Biaryl Catalyst for Asymmetric Acylation

Abstract

A new three-step synthesis and resolution of nucleophilic catalyst 1 suitable for large-scale preparation has been developed, and this catalyst has been shown to be effective for the kinetic resolution and asymmetric desymmetrization of a range of sec-alcohol substrates.