MicroRNAs<i> miR-1</i>,<i> miR-133a, miR-133b </i>and <i>miR-208</i> Are Dysregulated in Human Myocardial Infarction

Abstract

Our study showed the involvement of muscle- and/or cardiac-specific miRNAs miR-1, miR-133a/b and miR-208 in human MI. The most significant finding was upregulation of miR-208 and downregulation of miR-1 and miR-133a in MI compared to healthy adult hearts. Some patterns of miRNA expression were similar in MI and fetal hearts, supporting the concept of cardiac gene reprogramming in the remodeling of the heart.