Tryptase activates peripheral blood mononuclear cells causing the synthesis and release of TNF-α, IL-6 and IL-1β: possible relevance to multiple sclerosis

New diagnostic criteria for multiple sclerosis: Guidelines for research protocols

Charles M. Poser, Donald W. Paty, Labe C. Scheinberg et al. · Annals of Neurology · 1983 · 7.4K citations

Life Sciences, Neurology, Neuroscience +12

Cloning and characterization of human protease-activated receptor 4

Wenfeng Xu, Henrik Andersen, Theodore E. Whitmore et al. · Proceedings of the National Academy of Sciences · 1998 · 816 citations

Life Sciences, Molecular Biology, Cell Signaling +16

Mast Cells Are Essential for Early Onset and Severe Disease in a Murine Model of Multiple Sclerosis

Virginia H. Secor, W. Evan Secor, Claire-Anne Gutekunst et al. · The Journal of Experimental Medicine · 2000 · 427 citations · Full text

Life Sciences, Immunology, Neurology +17

Mast cell tryptase is a mitogen for cultured fibroblasts.

Stephen J. Ruoss, Tobias Hartmann, George H. Caughey · Journal of Clinical Investigation · 1991 · 392 citations · Full text

Life Sciences, Biochemistry, Cell Biology +15

Activation of Protease-Activated Receptor (PAR)-1, PAR-2, and PAR-4 Stimulates IL-6, IL-8, and Prostaglandin E2 Release from Human Respiratory Epithelial Cells

Nithiananthan Asokananthan, Peter T. Graham, Joshua Fink et al. · The Journal of Immunology · 2002 · 385 citations

Life Sciences, Cell Biology, Immunology +14