Formulation and characterization of biodegradable nanoparticles for intravascular local drug delivery

Polymers for the sustained release of proteins and other macromolecules

Róbert Langer, Judah Folkman · Nature · 1976 · 1.2K citations

Pharmacy, Materials Science, Pharmaceutics +14

Nanoparticle Uptake by the Rat Gastrointestinal Mucosa: Quantitation and Particle Size Dependency

Praful U. Jani, Gavin Halbert, John Langridge et al. · Journal of Pharmacy and Pharmacology · 1990 · 914 citations

Pharmacy, Pharmacokinetics, Bioavailability +13

Controlled Delivery Systems for Proteins Based on Poly(Lactic/Glycolic Acid) Microspheres

Smadar Cohen, Toshio Yoshioka, Melissa Lucarelli et al. · Pharmaceutical Research · 1991 · 845 citations

Pharmacy, Biomedical Engineering, Pharmaceutics +14

Aliphatic polyesters II. The degradation of poly (DL-lactide), poly (ε-caprolactone), and their copolymers in vivo

G.G. Pitt, Margit M. Gratzl, Gary L. Kimmel et al. · Biomaterials · 1981 · 844 citations

Natural Sciences, Biochemistry, Chemistry +12

Preparations of biodegradable nanospheres of water-soluble and insoluble drugs with D,L-lactide/glycolide copolymer by a novel spontaneous emulsification solvent diffusion method, and the drug release behavior

Toshiyuki Niwa, Hirofumi Takeuchi, Tomoya Hino et al. · Journal of Controlled Release · 1993 · 483 citations · Full text

Pharmacy, Pharmaceutics, Pharmacokinetics +17