Malignant transformation and mutagenesis in mammalian cells induced by vicinal diol-epoxides derived from benzo(a)pyrene

Metabolic activation of benzo(a)pyrene proceeds by a diol-epoxide

Peter Sims, P.L. Grover, Alan Swaisland et al. · Nature · 1974 · 1.1K citations

Life Sciences, Biochemistry, Metabolism +12

Identification of mutagenic metabolites of benzo(a)pyrene in mammalian cells.

Eliezer Huberman, Leo Sachs, Shen K. Yang et al. · Proceedings of the National Academy of Sciences · 1976 · 480 citations · Full text

Pharmacy, Toxicology, Carcinogenesis +16

Mammalian cell genetics. II. Chemical induction of specific locus mutations in Chinese hamster cells in vitro.

E.H.Y. Chu, H.V. Malling · Proceedings of the National Academy of Sciences · 1968 · 375 citations

Life Sciences, Cell Biology, Genetics +12

Exceptional mutagenicity of a benzo[a]pyrene diol epoxide in cultured mammalian cells

Robert F. Newbold, P. Brookes · Nature · 1976 · 270 citations

Pharmacy, Cell Biology, Toxicology +14

Cell‐mediated mutagenesis of mammalian cells with chemical carcinogens

Eliezer Huberman, Leo Sachs · International Journal of Cancer · 1974 · 243 citations

Medicine, Toxicology, Biochemical Toxicology +10