An oral sorbent reduces overload of indoxyl sulphate and gene expression of TGF‐β1 in uraemic rat kidneys

Abstract

AST-120 reduces the gene expression of TGF-beta1, TIMP-1 and pro-alpha1(I)collagen in the kidneys, and delays the progression of CRF, at least in part, by alleviating the overload of indoxyl sulphate on remnant proximal tubular epithelial cells.