Organic Letters · 2007 · 66 citations · 18 references
Natural SciencesChemistryMedicinal ChemistryBioorganic ChemistryOrganic ChemistrySynthetic Medicinal ChemistryHeterocycle SynthesisHeterocyclic ChemistryMacrocycle SynthesisOrganic SynthesisRetrosynthetic AnalysisAconitine BiosynthesisAmination ReactionsElectrophilic ReactivityNatural Product PharmacologyNatural Product SynthesisReactivityRing-forming ReactionsStereoselective Amination
A strategy for the preparation of aconitine is described that attempts to exploit chemoselective C-H amination and the electrophilic reactivity of oxathiazinane N,O-acetals for assembling the complex, polycyclic carbon framework of the natural product.
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