Cytogenetics and Cell Genetics · 2008 · 99 citations · 0 references
Life SciencesGeneticsMolecular GeneticsCytogeneticsDna RepairGenome OrganizationChromosome MappingDna Double-strand Break RepairDouble-strand Break RepairGene MappingGenetic MappingDna Damage Repair PathwaysDna In Situ HybridizationGenome-wide Repair MappingRestriction Fragment AnalysisRestriction Fragment Mapping
Three DNA repair genes, ERCC1, ERCC2, and XRCC1, have been regionally mapped on human chromosome 19. ERCC2 and XRCC1 have been assigned to bands q13.2----q13.3 by in situ hybridization using fluorescently-labeled cosmid probes. ERCC1 and ERCC2 have been found to be separated by less than 250 kb by large fragment restriction enzyme site mapping.