Strain differences of the ability to hydroxylate methotrexate in rats

Cancer Chemotherapy: Principles and Practice

Annals of Internal Medicine · 1990 · 572 citations

Medicine, Oncology, Pharmacology +12

Human Liver Aldehyde Oxidase: Differential Inhibition of Oxidation of Charged and Uncharged Substrates*

David G. Johns · Journal of Clinical Investigation · 1967 · 137 citations · Full text

Life Sciences, Biochemistry, Catalysis +12

The role of 7-hydroxymethotrexate during methotrexate anti-cancer therapy

Jan Lankelma, E Klein, Frans C. S. Ramaekers · Cancer Letters · 1980 · 107 citations

Medicine, Oncology, Pharmacotherapy +7

Presence of 2,4‐diamino‐N¹⁰‐methylpteroic acid after high‐dose methotrexate

Ross C. Donehower, Kenneth R. Hande, J C Drake et al. · Clinical Pharmacology & Therapeutics · 1979 · 98 citations

Medicine, Biochemistry, Pharmacology +8

Pharmacokinetics of methotrexate and 7-hydroxymethotrexate following infusions of high-dose methotrexate.

H. Breithaupt, E. Küenzlen · PubMed · 1982 · 89 citations

Pharmacy, Pharmacokinetics, Pharmacology +10