European Journal of Organic Chemistry · 2005 · 30 citations · 23 references
PharmacyChemistryMedicinal ChemistryDrug DiscoveryNatural Product BiosynthesisSynthetic Medicinal ChemistryAlkaloid BiosynthesisBioinorganic ChemistryMacrocycle SynthesisMarine Bioactive CompoundsMarine Natural Product BiosynthesisMarine Natural ProductsAlkaloid Skeleton FormationBioactive Compounds From Marine SpongesBiosynthetic Pathways Of Marine Natural ProductsMarine AlkaloidsMarine Sponge MetabolitesPlant AlkaloidsSponges As Drug SourcesSponges-derived Metabolites
Abstract Sarain A is a complex macrocyclic marine alkaloid extracted from sponges of the order Haplosclerida . It is likely that this alkaloid shares a common origin with manzamine alkaloids, also extracted from sponges of the same order. In this paper, new concepts concerning this origin are presented and constitute the basis for a synthetic strategy. A preliminary evaluation of this strategy is presented and leads, as a first result, to a five‐step access to the bicyclic intermediate 43 . (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2005)
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On the Biosynthesis of Manzamines
Jack E. Baldwin, Roger C. Whitehead · Tetrahedron Letters · 1992 · 193 citations
Alexander Kaiser, Xavier Billot, Alice Gateau‐Olesker et al. · Journal of the American Chemical Society · 1998 · 89 citations