Derek J. Denhart

Enantioselective Synthesis of a Highly Potent Selective Serotonin Reuptake Inhibitor. An Application of Imidazolidinone Catalysis to the Alkylation of Indoles with an α,β-Disubstituted α,β-Unsaturated Aldehyde

Dalton King, Zhaoxing Meng, Derek J. Denhart et al. · Organic Letters · 2005 · 123 citations

Asymmetric Catalysis, Medicinal Chemistry, Enantioselective Synthesis +15

Synthesis of the Tricyclic Core of Sarain A. Use of Formaldehyde in an Intramolecular Grigg Azomethine Ylide Cyclization

Derek J. Denhart, David A. Griffith, Clayton H. Heathcock · The Journal of Organic Chemistry · 1998 · 70 citations

Sarain A, Engineering, Heterocyclic +12

Studies Related to the Carbohydrate Sectors of Esperamicin and Calicheamicin: Definition of the Stability Limits of the Esperamicin Domain and Fashioning of a Glycosyl Donor from the Calicheamicin Domain

Randall L. Halcomb, Serge H. Boyer, Mark D. Wittman et al. · Journal of the American Chemical Society · 1995 · 64 citations

Pharmaceutical Science, Bioorganic Chemistry, Glycobiology +17

A Strategy to Minimize Reactive Metabolite Formation: Discovery of (<i>S</i>)-4-(1-Cyclopropyl-2-methoxyethyl)-6-[6-(difluoromethoxy)-2,5-dimethylpyridin-3-ylamino]-5-oxo-4,5-dihydropyrazine-2-carbonitrile as a Potent, Orally Bioavailable Corticotropin-Releasing Factor-1 Receptor Antagonist

Richard A. Hartz, Vijay T. Ahuja, Xiaoliang Zhuo et al. · Journal of Medicinal Chemistry · 2009 · 54 citations · Full text

Pharmaceutical Science, Metabolic Characterization, Receptor Antagonist +16

In Vitro Intrinsic Clearance-Based Optimization of<i>N</i>³-Phenylpyrazinones as Corticotropin-Releasing Factor-1 (CRF₁) Receptor Antagonists

Richard A. Hartz, Vijay T. Ahuja, Maria Rafalski et al. · Journal of Medicinal Chemistry · 2009 · 37 citations · Full text