A human major histocompatibility complex class I gene that encodes a protein with a shortened cytoplasmic segment.

TLDR

The authors cloned a 6.0‑kb genomic fragment encoding a non‑HLA‑A/B/C class I gene. The cloned HLA‑6.0 gene encodes a class I protein homologous to HLA‑A/B but with a truncated cytoplasmic tail, and its promoter resembles Qa‑region genes, indicating it is a structural homolog of murine Qa class I.

Abstract

We have cloned genomic DNA encoding a non-HLA-A, -B, -C class I gene located within a HindIII-generated restriction fragment of 6.0 kilobase pairs. This gene, designated HLA-6.0, is as homologous to HLA-A and HLA-B as they are to each other. The HLA class I protein encoded by HLA-6.0 is similar in organization to the HLA-A-, -B-, and -C-encoded proteins except that an in-frame termination codon prevents translation of a majority of the cytoplasmic region of the HLA-6.0 polypeptide. Moreover, the promoter region of HLA-6.0 resembles the promoter region of a Qa region gene. These structural features of HLA-6.0 suggest that this non-HLA-A, -B, -C gene is a structural homolog of a murine Qa region class I gene.