PLoS ONE · 2013 · 39 citations · 34 references
Life SciencesGeneticsImmunologyAutoimmunityHuman GeneticsImmunogeneticsAutoimmune Disease Susceptibility GenesAutoimmune DiseasesDisease Susceptibility LociGenetic SusceptibilityGenetic Susceptibility To AutoimmunityGenotype-phenotype Association AnalysisAge-related Disease Susceptibility GeneticsAutoimmune Disease GeneticsEnvironmental FactorsGenetic Risk VariantsHla Allele PolymorphismHla Genotype AssociationsHla Risk AllelesImmune Response Gene Variants
BACKGROUND: Graves' disease (GD) is a complex disease in which genetic predisposition is modified by environmental factors. The aim of the study was to examine the association between genetic variants in genes encoding proteins involved in immune response and the age at diagnosis of GD. METHODS: 735 GD patients and 1216 healthy controls from Poland were included into the study. Eight genetic variants in the HLA-DRB1, TNF, CTLA4, CD40, NFKb, PTPN22, IL4 and IL10 genes were genotyped. Patients were stratified by the age at diagnosis of GD and the association with genotype was analysed. RESULTS: Polymorphism in the HLA-DRB1, TNF and CTLA4 genes were associated with GD. The carriers of the HLA DRB1*03 allele were more frequent in patients with age at GD diagnosis ≤30 years than in patients with older age at GD diagnosis. CONCLUSIONS: HLADRB1*03 allele is associated with young age at diagnosis of Graves' disease in Polish population.
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Association of the T-cell regulatory gene CTLA4 with susceptibility to autoimmune disease
Hironori Ueda, Joanna M. M. Howson, Laura Esposito et al. · Nature · 2003 · 2.2K citations
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Tsuyoshi Kouki, Yoshikuni Sawai, Cyprian A. Gardine et al. · The Journal of Immunology · 2000 · 505 citations · Full text
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