The main Hepatitis B virus (HBV) mutants resistant to nucleoside analogs are susceptible in vitro to non-nucleoside inhibitors of HBV replication

Quantitative analysis of dose-effect relationships: the combined effects of multiple drugs or enzyme inhibitors

Ting‐Chao Chou, Paul Talalay · Advances in Enzyme Regulation · 1984 · 7.1K citations

Pharmacological Study, Pharmacoepidemiology, Quantitative Analysis +10

Exploitable mechanisms in combined radiotherapy-chemotherapy: The concept of additivity

G. Gordon Steel, Michael Peckham · International Journal of Radiation Oncology*Biology*Physics · 1979 · 904 citations

Adaptive Radiotherapy, Radiobiology, Radiation Therapy +6

Inhibition of Hepatitis B Virus Replication by Drug-Induced Depletion of Nucleocapsids

Karl Deres, Claus H. Schröder, Arnold Paessens et al. · Science · 2003 · 502 citations

Immunology, Hepatitis B, Molecular Biology +18

Generalized Equations for the Analysis of Inhibitions of Michaelis-Menten and Higher-Order Kinetic Systems with Two or More Mutually Exclusive and Nonexclusive Inhibitors

Ting‐Chao Chou, Paul Talalay · European Journal of Biochemistry · 2005 · 421 citations · Full text

Michaelis-menten Kinetics, Pharmacotherapy, Pharmacodynamic Modeling +19

A heteroaryldihydropyrimidine activates and can misdirect hepatitis B virus capsid assembly

Stephen J. Stray, Christina R. Bourne, Sreenivas Punna et al. · Proceedings of the National Academy of Sciences · 2005 · 259 citations · Full text

Viral Replication, Biochemistry, Synthetic Virology +13