Synthesis and reactions of esters of <i>N</i>‐hydroxyphthalimide and <i>N</i>‐protected amino acids

Abstract

Abstract Esters can be prepared from N ‐hydroxyphthalimide and N ‐carbobenzoxy‐ or N ‐phthaloyl‐amino acids using dicyclohexylcarbodi‐imide as condensing agent. The compounds are suitable for the stepwise synthesis of peptides without racemization. With methanol the N ‐hydroxyphthalimide ester of N ‐phthaloylglycine can be converted into the methyl ester of N ‐phthaloylglycine.