Down-Regulation of CDH1 Is Associated with Expression of SNAI1 in Colorectal Adenomas

Abstract

Our data show that SNAI1 and Twist1 are already expressed in benign precursor lesions of colorectal cancer and that SNAI1 expression was significantly correlated with lower expression of CDH1. Whether these findings reflect true EMT and/or are a sign of a more aggressive biology need to be investigated in further studies.