Concepedia

A sensitive assay for ZD1839 (Iressa) in human plasma by liquid–liquid extraction and high performance liquid chromatography with mass spectrometric detection: validation and use in Phase I clinical trials

Helen Jones, Lesley E. Stafford, Helen Swaisland, Richard K. Payne

Journal of Pharmaceutical and Biomedical Analysis · 2002 · 64 citations · 11 references

References

11

Antitumor effect and potentiation of cytotoxic drugs activity in human cancer cells by ZD-1839 (Iressa), an epidermal growth factor receptor-selective tyrosine kinase inhibitor.

Fortunato Ciardiello, R. Caputo, Roberto Bianco et al. · PubMed · 2000 · 938 citations

Medicine, Medicinal Chemistry, Pharmacology +17

BindingDB Entry 50022536: Induction of apoptosis and cell cycle arrest by CP-358,774, an inhibitor of epidermal growth factor receptor tyrosine kinase.

PubMed · 2025 · 844 citations · Full text

Medicine, Oncology, Pharmacology +17

The Biologic Effects of C225, A Chimeric Monoclonal Antibody to the EGFR, on Human Prostate Carcinoma

Marie Prewett, Howard I. Scher, Patricia Rockwell et al. · Journal of Immunotherapy · 1996 · 244 citations · Full text

Medicine, Oncology, Pharmacology +16

Pharmacokinetics and Tolerability of the Orally Active Selective Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor ZD1839 in Healthy Volunteers

Helen Swaisland, Alison Laight, Lesley E. Stafford et al. · Clinical Pharmacokinetics · 2001 · 119 citations

Medicine, Pharmacokinetics, Pharmacology +6

A New Approach for Dealing with the Stability of Drugs in Biological Fluids

U. Timm, Michael Wall, D. Dell · Journal of Pharmaceutical Sciences · 1985 · 102 citations

Pharmacy, Pharmaceutics, Pharmacokinetics +7