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A sensitive assay for ZD1839 (Iressa) in human plasma by liquid–liquid extraction and high performance liquid chromatography with mass spectrometric detection: validation and use in Phase I clinical trials

Analytical InstrumentationBioanalysisPharmacologyMass SpectrometrySensitive AssayLaboratory MedicineHuman PlasmaLiquid–liquid ExtractionAnalytical ChemistryLiquid ChromatographyClinical ChemistryChromatographic AnalysisMedicineChromatographyDrug Analysis