Candidate biomarkers of PARP inhibitor sensitivity in ovarian cancer beyond the BRCA genes

Darren Hodgson, Brian Dougherty, Zhongwu Lai, +16

British Journal of Cancer

Seven-Day Remote Ischemic Preconditioning Improves Local and Systemic Endothelial Function and Microcirculation in Healthy Humans

Helen Jones, Nicola D. Hopkins, Tom G. Bailey, +3

American Journal of Hypertension

Pharmacokinetics and Tolerability of the Orally Active Selective Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor ZD1839 in Healthy Volunteers

Helen Swaisland, Alison Laight, Lesley E. Stafford, +4

Clinical Pharmacokinetics

MedicineHealthy VolunteersSkin PharmacologyPharmacotherapyDermatology +1

Phase I clinical evaluation of ZD6126, a novel vascular-targeting agent, in patients with solid tumors

Patricia LoRusso, Shirish M. Gadgeel, Antoinette Wozniak, +7

Investigational New Drugs

Drug TargetingAngiogenesisSolid TumorsMedicinePharmacology +8

Post‐Exercise Blood Pressure Reduction Is Greater Following Intermittent Than Continuous Exercise and Is Influenced Less by Diurnal Variation

Helen Jones, Chloe E. Taylor, Nia C. S. Lewis, +2

Chronobiology International

HypertensionPhysical ActivityBlood Pressure VariabilityBlood PressureKinesiology +16

A sensitive assay for ZD1839 (Iressa) in human plasma by liquid–liquid extraction and high performance liquid chromatography with mass spectrometric detection: validation and use in Phase I clinical trials

Helen Jones, Lesley E. Stafford, Helen Swaisland, +1

Journal of Pharmaceutical and Biomedical Analysis

Analytical InstrumentationBioanalysisPharmacologyMass SpectrometrySensitive Assay +10

ATM protein is deficient in over 40% of lung adenocarcinomas

Liza C. Villaruz, Helen Jones, Shira Abberbock, +8

Oncotarget

Atm ProteinOncologyProtein FunctionAdvanced Lung DiseaseNuclear Atm Protein +12

Diurnal variation in time to presyncope and associated circulatory changes during a controlled orthostatic challenge

Nia C. S. Lewis, Greg Atkinson, Samuel J. E. Lucas, +5

American Journal of Physiology-Regulatory, Integrative and Comparative Physiology

Homeostatic MechanismPhysiological RegulationBlood PressureCerebral Vascular RegulationOrthostatic Challenge +19

Exercise Intensity and Blood Pressure During Sleep

Helen Jones, Keith George, Ben Edwards, +1

International Journal of Sports Medicine

Sleep DisordersHypertensionPhysical ActivityBlood Pressure VariabilityBlood Pressure +22

Diurnal Variation in the Mechanical and Neural Components of the Baroreflex

Chloe E. Taylor, Greg Atkinson, Christopher K. Willie, +3

Hypertension

HypertensionPressure MeasurementBlood Pressure VariabilityModified Oxford MethodCarotid Artery Diameter +24