Secondary Metabolites from the Sponge <i>Tedania </i><i>anhelans:</i> Isolation and Characterization of Two Novel Pyrazole Acids and Other Metabolites

Abstract

Chemical investigation of the methanol extract of the sponge Tedania anhelans yielded the two unusual heteroaromatic acids, pyrazole-3(5)-carboxylic acid (2) and 4-methylpyrazole-3(5)-carboxylic acid (3), which are reported for the first time as natural products. The other compounds isolated were p-hydroxybenzaldehyde, phenylacetamide, 3-phenylpropionic acid, 3-(p-hydroxyphenyl)propionic acid, 3-(p-methoxyphenyl)propionic acid, β-carboline (norharman) (1), and the four diketopiperazines pro-val, pro-leu, pro-phe, and pro-tyr.