Pteropodine and isopteropodine positively modulate the function of rat muscarinic M1 and 5-HT2 receptors expressed in Xenopus oocyte

Tai‐Hyun Kang, Kinzo Matsumoto, Michihisa Tohda, +4

European Journal of Pharmacology

Signal TransductionMedicine5-Ht2 ReceptorsPhysiologyXenopus Oocyte +8

Selenosugars are key and urinary metabolites for selenium excretion within the required to low-toxic range

Yayoi Kobayashi, Yasumitsu Ogra, Kazuya Ishiwata, +3

Proceedings of the National Academy of Sciences

Studies on the Synthesis and Opioid Agonistic Activities of Mitragynine-Related Indole Alkaloids:  Discovery of Opioid Agonists Structurally Different from Other Opioid Ligands

Hiromitsu Takayama, Hayato Ishikawa, Mika Kurihara, +10

Journal of Medicinal Chemistry

Medicinal ChemistryMitragyna SpeciosaPharmacological StudyMedicinePhysiology +11

Antinociceptive effect of 7-hydroxymitragynine in mice: Discovery of an orally active opioid analgesic from the Thai medicinal herb Mitragyna speciosa

Kenjiro Matsumoto, Syunji Horie, Hayato Ishikawa, +4

Life Sciences

Medicinal ChemistryPharmacological StudyPain MedicineMedicineActive Opioid Analgesic +8

Central antinociceptive effects of mitragynine in mice: contribution of descending noradrenergic and serotonergic systems

Kinzo Matsumoto, Maho Mizowaki, Thongpradichote Suchitra, +4

European Journal of Pharmacology

Health SciencesNeurophysiologyPain MedicineMedicinePhysiology +10

Camptothecin Biosynthetic Genes in Hairy Roots of Ophiorrhiza pumila: Cloning, Characterization and Differential Expression in Tissues and by Stress Compounds

Yasuyo Yamazaki, Hiroshi Sudo, Mami Yamazaki, +2

Plant and Cell Physiology

Plant PhysiologyEngineeringBotanyMolecular BiologyPlant Biochemistry +18

Antinociceptive action of mitragynine in mice: Evidence for the involvement of supraspinal opioid receptors

Kinzo Matsumoto, Maho Mizowaki, Thongpradichote Suchitra, +3

Life Sciences

Molecular PharmacologyHealth SciencesPain MedicineMedicinePhysiology +10

Antioxidant and cytotoxic flavonoids from the flowers of Melastoma malabathricum L.

Deny Susanti Darnis, Hasnah Mohd Sirat, Farediah Ahmad, +3

Food Chemistry

Cytotoxic FlavonoidsMelastoma Malabathricum LBotanyMedicinePhytochemical +3

Feasible production of camptothecin by hairy root culture of Ophiorrhiza pumila

Kazuki Saito, Hiroshi Sudo, Mami Yamazaki, +4

Plant Cell Reports

Hairy Root CultureBiosynthesisEngineeringBotanyMicropropagation +7

Metabolite profiling of alkaloids and strictosidine synthase activity in camptothecin producing plants

Yasuyo Yamazaki, Akiko Urano, Hiroshi Sudo, +5

Phytochemistry

BiosynthesisMetabolite ProfilingEngineeringBiochemistryMedicine +8