Studies on the Synthesis and Opioid Agonistic Activities of Mitragynine-Related Indole Alkaloids:  Discovery of Opioid Agonists Structurally Different from Other Opioid Ligands

Hiromitsu Takayama, Hayato Ishikawa, Mika Kurihara, +10

Journal of Medicinal Chemistry

Medicinal ChemistryMitragyna SpeciosaPharmacological StudyMedicinePhysiology +11

Antinociceptive effect of 7-hydroxymitragynine in mice: Discovery of an orally active opioid analgesic from the Thai medicinal herb Mitragyna speciosa

Kenjiro Matsumoto, Syunji Horie, Hayato Ishikawa, +4

Life Sciences

Medicinal ChemistryPharmacological StudyPain MedicineMedicineActive Opioid Analgesic +8

Inhibitory effect of mitragynine, an alkaloid with analgesic effect from thai medicinal plant Mitragyna speciosa, on electrically stimulated contraction of isolated guinea-pig ileum through the opioid receptor

Kazuo Watanabe, Shingo Yano, Syunji Horie, +1

Life Sciences

Isolated Guinea-pig IleumPharmacological StudyPain MedicineMedicinePhysiology +8

Opioid receptor agonistic characteristics of mitragynine pseudoindoxyl in comparison with mitragynine derived from Thai medicinal plant Mitragyna speciosa

Leonardo T. Yamamoto, Syunji Horie, Hiromitsu Takayama, +7

General Pharmacology The Vascular System

Pharmacological StudyMedicineMitragynine PseudoindoxylNeuropharmacologyExperimental Pharmacology +5

Antinociception, tolerance and withdrawal symptoms induced by 7-hydroxymitragynine, an alkaloid from the Thai medicinal herb Mitragyna speciosa

Kenjiro Matsumoto, Syunji Horie, Hiromitsu Takayama, +5

Life Sciences

Medicinal ChemistryPharmacological StudyMedicineHerbal MedicineHerb-drug Interaction +6

Involvement of μ-opioid receptors in antinociception and inhibition of gastrointestinal transit induced by 7-hydroxymitragynine, isolated from Thai herbal medicine Mitragyna speciosa

Kenjiro Matsumoto, Yoshio Hatori, Toshihiko Murayama, +6

European Journal of Pharmacology

Pain DisordersHealth SciencesPain MedicineGastrointestinal PharmacologyPhysiology +9

Contractile effect of TRPA1 receptor agonists in the isolated mouse intestine

Angelica Penuelas, Kimihito Tashima, Shizuko Tsuchiya, +4

European Journal of Pharmacology

Molecular PhysiologySignal TransductionTrpa1 Receptor AgonistsMedicinePhysiology +8

Phenolic compounds from Gastrodia rhizome and relaxant effects of related compounds on isolated smooth muscle preparation

Junko Hayashi, Toshikazu Sekine, Shigeyoshi Deguchi, +6

Phytochemistry

Phenolic CompoundsBiochemistryPhysiologyOrganic ChemistryGastrodia Rhizome +5

Effects of hirsutine, an antihypertensive indole alkaloid from Uncaria rhynchophylla, on intracellular calcium in rat thoracic aorta

Syunji Horie, Shingo Yano, Norio Aimi, +2

Life Sciences

HypertensionRat Thoracic AortaMedicinePhysiologyHerb-drug Interaction +6

Inhibitory effect of mitragynine, an analgesic alkaloid from Thai herbal medicine, on neurogenic contraction of the vas deferens

Kenjiro Matsumoto, Leonardo T. Yamamoto, Kazuo Watanabe, +6

Life Sciences

Health SciencesPain MedicineMedicinePhysiologyHerbal Medicine +9