PolyADP-Ribosylation Is Required for Pronuclear Fusion during Postfertilization in Mice

Abstract

Our findings indicate that PARylation is required for pronuclear fusion during postfertilization processes. These data further suggest that PARylation regulates protein dynamics essential for the beginning of mouse zygotic development. PARylation and its involving signal-pathways may represent potential targets as contraceptives.