Soy flour nanoparticles for controlled drug delivery: effect of crosslinker and montmorillonite (MMT)

Abstract

Soy flour (SF)–Montmorillonite (MMT) nanoparticles crosslinked with glutaraldehyde (GA) have been made and used as a carrier for isoniazid. The nanoparticles have been characterized by fourier transmission infra-red spectroscopy (FTIR), X-ray diffractometry (XRD), scanning electron microscopy (SEM) and transmission emission microscopy (TEM). The effects of MMT and glutaraldehyde on the nanoparticles have been assessed with regard to swelling, encapsulation efficiency and consequently, the release of isoniazid in different mediums. The drug release mechanism has been studied for different time periods by UV-Vis spectroscopy. Cytotoxicity testing has been performed by MTT assay analysis. The results imply that the nanoparticles can be exploited as a potential drug carrier for controlled release applications.