Least-squares integration method in intensity fluctuation spectroscopy of macromolecular solutions with bimodal distributions

Abstract

This letter presents a new least-squares integration method of analysis for time-dependent correlation functions consisting of two exponentials. It also contains an investigation of the effect of sample time on the accuracy that can be achieved in a given intensity correlation measurement by means of 24- and 48-channel single-clipped photon-correlation spectrometers. Comparison is made with the least-squares normal equation method using experimental as well as simulated results.